https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 A pathogenic role for tumor necrosis factor-related apoptosis-inducing ligand in chronic obstructive pulmonary disease https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21994 Thu 28 Oct 2021 12:36:38 AEDT ]]> Animal and translational models of SARS-CoV-2 infection and COVID-19 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38615 Thu 25 Nov 2021 14:39:42 AEDT ]]> The inhibitor of semicarbazide-sensitive amine oxidase, PXS-4728A, ameliorates key features of chronic obstructive pulmonary disease in a mouse model https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30071 Thu 24 Mar 2022 11:36:47 AEDT ]]> Targeting PP2A and proteasome activity ameliorates features of allergic airway disease in mice https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33082 (S)), or inhibiting proteasome activity with bortezomib (BORT), could suppress experimental AAD. Methods: Acute AAD was induced in C57BL/6 mice by intraperitoneal sensitization with ovalbumin (OVA) in combination with intranasal (i.n) exposure to OVA. Chronic AAD was induced in mice with prolonged i.n exposure to crude house dust mite (HDM) extract. Mice were treated with vehicle, FTY720, AAL(S), BORT or AAL(S)+- BORT and hallmark features of AAD assessed. Results: AAL(S) reduced the severity of acute AAD by suppressing tissue eosinophils and inflammation, mucus-secreting cell (MSC) numbers, type 2-associated cytokines (interleukin (IL)-33, thymic stromal lymphopoietin, IL-5 and IL-13), serum immunoglobulin (Ig)E and airway hyper-responsiveness (AHR). FTY720 only suppressed tissue inflammation and IgE. BORT reduced bronchoalveolar lavage fluid (BALF) and tissue eosinophils and inflammation, IL-5, IL-13 and AHR. Combined treatment with AAL(S)+BORT had complementary effects and suppressed BALF and tissue eosinophils and inflammation, MSC numbers, reduced the production of type 2 cytokines and AHR. AAL (S) , BORT and AAL (S) +BORT also reduced airway remodelling in chronic AAD. Conclusion: These findings highlight the potential of combination therapies that enhance PP2A and inhibit proteasome activity as novel therapeutic strategies for asthma.]]> Thu 17 Mar 2022 14:36:39 AEDT ]]> Mucosal production of uric acid by airway epithelial cells contributes to particulate matter-induced allergic sensitization https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21993 Thu 14 Apr 2022 11:02:37 AEST ]]> Mucosal production of uric acid by airway epithelial cells contributes to particulate matter-induced allergic sensitization https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29496 Thu 14 Apr 2022 10:58:05 AEST ]]>